Transcription Activation at Class II CAP-Dependent Promoters: Two Interactions between CAP and RNA Polymerase
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Transcription Activation at Class II CAP-Dependent Promoters: Two Interactions between CAP and RNA Polymerase
Class II CAP-dependent promoters, interacting with the RNAP ␣ subunit C-terminal domain (␣CTD) and facilitat-At Class I CAP-dependent promoters, interaction between the activating region and ␣CTD (and concomitant St. Louis, Missouri 63104 recruitment of RNAP to promoter DNA) appears to be the entire basis of transcription activation. Thus, at Class Summary I CAP-dependent promoters, removal of ...
متن کاملTranscription activation at class II CAP-dependent promoters.
Transcription activation at Class II CAP-dependent promoters provides a paradigm for understanding how a single activator molecule can make multiple interactions with the transcription machinery, with each interaction being responsible for a specific mechanistic consequence. At Class II CAP-dependent promoters, the DNA target site for CAP is centred near position -42, overlapping and replacing ...
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Transcription activation by Escherichia coli catabolite activator protein (CAP) at each of two classes of simple CAP-dependent promoters is understood in structural and mechanistic detail. At class I CAP-dependent promoters, CAP activates transcription from a DNA site located upstream of the DNA site for RNA polymerase holoenzyme (RNAP); at these promoters, transcription activation involves pro...
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Gene expression is a process integral to cell proliferation. The E2F family of transcription factors upregulates expression of transcripts whose products are essential for cell cycle progression. Here, we report that E2F1 promotes gene expression by an additional mechanism, that is, formation of the methyl cap on RNA pol II transcripts. The methyl cap is required for mRNA maturation, expression...
متن کاملTranscription activation at Class II CRP-dependent promoters: identification of determinants in the C-terminal domain of the RNA polymerase alpha subunit.
Many transcription factors, including the Escherichia coli cyclic AMP receptor protein (CRP), act by making direct contacts with RNA polymerase. At Class II CRP-dependent promoters, CRP activates transcription by making two such contacts: (i) an interaction with the RNA polymerase alpha subunit C-terminal domain (alphaCTD) that facilitates initial binding of RNA polymerase to promoter DNA; and ...
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ژورنال
عنوان ژورنال: Cell
سال: 1996
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81806-1